Publications

Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filamentNature Communications2025-01-24DOI: 10.1038/s41467-025-56127-yAuthors: Emmajay Sutherland; Christopher J. Harding; Tancrède du Monceau de Bergendal; Gordon J. Florence; Katrin Ackermann; Bela E. Bode; Silvia Synowsky; Ramasubramanian Sundaramoorthy; Clarissa Melo Czekster

Snapshots of the reaction coordinate of a thermophilic 2-deoxyribonucleoside/ribonucleoside TransferaseACS Catalysis 14(5), 3090-3102.DOI: 10.1021/acscatal.3c06260Authors: Peng Tang; Christopher J. Harding; Alex Dickson; R. G. da Silva; David Harrison; Clarissa Melo Czekster

Unveiling the catalytic mechanism of a processive metalloaminopeptidaseBiochemistry 62(22), 3188-3205.DOI: 10.1021/acs.biochem.3c00420Authors: M. C. Simpson; Christopher J. Harding; R. M. Czekster; L. Remmel; B. Bode; Clarissa Melo Czekster

An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosaNature Chemical Biology.DOI: 10.1038/s41589-023-01373-8Authors: Christopher J. Harding; M. Bergkessel; M. Bischoff; Clarissa Melo Czekster

Active site remodelling of a cyclodipeptide synthase redefines substrate scopeNature Communications Chemistry 5, 101.DOI: 10.1038/s42004-022-00715-2Authors: Emmajay Sutherland; Christopher J. Harding; Clarissa Melo Czekster

Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzymeRSC Chemical Biology 2, 230-240.DOI: 10.1039/d0cb00142bAuthors: Christopher J. Harding; Emmajay Sutherland; J. G. Hanna; D. R. Houston; Clarissa Melo Czekster

A Rotary Mechanism for Allostery in Bacterial Hybrid Malic EnzymesNature Communications 12, 1228.DOI: 10.1038/s41467-021-21528-2Authors: Christopher J. Harding et al.

A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorusNature Communications 11.DOI: 10.1038/s41467-020-18139-8Authors: Christopher J. Harding et al.

Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport systemNature Microbiology 4, 1692-1705.DOI: 10.1038/s41564-019-0481-yAuthors: G. W. Hughes et al.

Target highlights in CASP13: Experimental target structures through the eyes of their authorsProteins-Structure Function and Bioinformatics 87, 1037-1057.DOI: 10.1002/prot.25805Authors: R. Lepore et al.